the effects of nigella sativa hydro-alcoholic extract on memory and brain tissues oxidative damage after repeated seizures in rats

نویسندگان

farzaneh vafaee neurogenic inflammation research center, department of physiology, school of medicine, mashhad, university of medical sciences, mashhad, iran

mahmoud hosseini neurocognitive research center, department of physiology, school of medicine, mashhad, university of medical sciences, mashhad, iran

zahra hassanzadeh department of biology, faculty of basic sciences, fars science and research branch, islamic azad university, shiraz, iran

mohammad amin edalatmanesh department of biology, faculty of basic sciences, fars science and research branch, islamic azad university, shiraz, iran

چکیده

regarding the therapeutic properties of nigella sativa (ns), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (ptz) - induced repeated seizures.there were 4 experimental groups including: 1- control group; received saline, 2- ptz group ; received saline and ptz (50 mg/kg, i.p) , 3-ptz- ns 200 and 4- ptz- ns 400 ; received 200 and 400 mg/kg of ns extract respectively, before ptz injection in 5 consecutive days. seizure scores were lower in ptz – ns 200 and 400, furthermore the seizure onset latencies were higher in these groups than ptz group (pit is concluded that the hydro-alcoholic extract of ns posses beneficial effects on learning and memory impairments in repeated seizures model which is accompanied by antioxidant effects in the brain.

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The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...

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The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4...

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The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro - alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures. There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/Kg, i.p) , 3-PTZ- NS 200 and ...

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۴، شماره ۲، صفحات ۵۴۷-۵۵۷

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